Peptide microarrays coupled to machine learning reveal individual epitopes from human antibody responses with neutralizing capabilities against SARS-CoV-2기계 학습과 결합된 펩티드 마이크로어레이는 SARS-CoV-2에 대한 중화 기능을 가진 인간 항체 반응의 개별 에피토프를 나타냅니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료법, [키워드] anti-SARS-CoV-2 antibody Antibody binding assays binding epitope capture causative agent cellular coronavirus coronavirus SARS-CoV-2 Course COVID-19 detectable epitope Epitopes human antibody response IgA IgG IgM antibody immunoassays incubated infected with SARS-CoV-2 machine learning Microarray N-terminus negative control samples neutralization neutralization assays Neutralizing Neutralizing antibodies nine overlapping Patient peptide peptide arrays peptides positive protective effect Protective effects random Random forest response S protein SARS CoV SARS CoV-2 SARS-CoV-2 sera serology Serology. Specific structural protein structural proteins the disease the S protein vaccine candidate vaccine candidates Viral [DOI] 10.1080/22221751.2022.2057874 PMC 바로가기 [Article Type] Article
Advancing Precision Vaccinology by Molecular and Genomic Surveillance of Severe Acute Respiratory Syndrome Coronavirus 2 in Germany, 20212021년 독일에서 중증 급성 호흡기 증후군 코로나바이러스 2의 분자 및 게놈 감시를 통한 정밀 백신학 발전Article Published on 2022-08-152022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 유전자 메커니즘, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Advancing Alpha variant Analysis analysis approach Beta collected complement Comprehensive contributed coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 dataset deceleration Delta wave Effectiveness effort estimate Evolution expansion facilitated Genetic genomic genomic sequencing Genomic surveillance Germany GISAID immune evasion in vitro incidence incidence estimation indicated Laboratory molecular molecular surveillance Multiple multiple mutations Mutation National neutralization assays observation period pathogen pathogen genomics Phylogenetic analysis powerful tool Precision Public public health Randomly respiratory resulting Robert Koch SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 genomic surveillance sequence sequenced sample Spread Surveillance the SARS-CoV-2 undergo vaccination Vaccination strategies Vaccination strategy Vaccine variant Variant of concern. variants of concern virus whole-genome sequencing [DOI] 10.1093/cid/ciac399 PMC 바로가기 [Article Type] Article
Discovery and intranasal administration of a SARS-CoV-2 broadly acting neutralizing antibody with activity against multiple Omicron subvariantsArticle Published on 2022-08-082022-10-06 Journal: Med (New York, N.Y.) [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acting acute respiratory syndrome Administered administration antibody approved B.1.1.529 breadth cell line cGMP characterized coronavirus COVID-19 CRIPT DARPA defined diagnosed domains Emergency use FDA H2L2 mice Harbor human clinical trials human IgG1 intranasal intranasally intravenous intravenously K18-hACE2 transgenic mice LALA limit lineages Live virus lung titer NAb neutralization assays Neutralizing Neutralizing activity neutralizing antibody omicron Omicron BA.1 Omicron BA.1.1 Omicron BA.2 Pre-clinical research provided pseudotype quantitation reduced required retained SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike subset tested therapeutic Therapies treat vaccination variant variants of concern variants of concern. virus weight loss [DOI] 10.1016/j.medj.2022.08.002 PMC 바로가기 [Article Type] Article
Development of a Rapid Live SARS-CoV-2 Neutralization Assay Based on a qPCR ReadoutqPCR 판독을 기반으로 한 Rapid Live SARS-CoV-2 중화 분석의 개발Article Published on 2022-07-202022-09-11 Journal: Journal of Clinical Microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] antibody Antibody-mediated immunity antiviral activity calculate can be used characteristic controls correlation COVID-19 COVID-19 pandemic cross-neutralization demonstrated detect determine determined by development domain ELISA experiments faster generate gold gold standard Immunity Live virus natural infection neutralization Neutralization assay neutralization assays Neutralizing Neutralizing antibodies neutralizing antibody patient sera priority qPCR qRT-PCR Rapid Receptor-binding domain reduce reduction SARS-CoV-2 SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 qRT-PCR Sensitivity and specificity sera significantly standard curve Surrogate neutralization assay. tested vaccination variants Vero E6 Vero E6 cell VERO E6 cells Viral Viral load Viral RNA virus virus isolate Virus neutralization [DOI] 10.1128/jcm.00376-22 PMC 바로가기 [Article Type] Article
Overview of Neutralization Assays and International Standard for Detecting SARS-CoV-2 Neutralizing AntibodySARS-CoV-2 중화 항체 검출을 위한 중화 분석 및 국제 표준 개요Review Published on 2022-07-182022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antibody Response Antibody responses Antibody titer approach coronavirus coronavirus disease demonstrated detect determine disease disease outbreak Efficacy ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Health Organization International international standard international standard for SARS-CoV-2 International standards lateral flow microneutralization Microneutralization assay MONITOR Neutralization assay neutralization assays Neutralizing antibodies neutralizing antibody neutralizing antibody detection Neutralizing antibody titer outbreak outcome Patient respiratory SARS-CoV-2 SARS-CoV-2 pseudotype virus Serological assay serological assays serological assays. severe acute respiratory syndrome Coronavirus Standard to define Vaccine vaccine efficacy World Health Organization [DOI] 10.3390/v14071560 PMC 바로가기 [Article Type] Review
Recipients of COVID-19 vaccines face challenges of SARS-CoV-2 variantsCOVID-19 백신 수혜자들은 SARS-CoV-2 변종에 대한 도전에 직면해 있습니다.Review Published on 2022-07-112022-09-11 Journal: International Journal of Biological Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] affecting anti-SARS-CoV-2 antibody booster booster vaccination booster vaccination. Booster vaccine booster vaccines coronavirus coronavirus disease COVID-19 COVID-19 vaccine death dose Effectiveness Efficacy evade expected global public health immune protection immune response Immunological Surveillance in vitro Infection neutralization Neutralization assay neutralization assays neutralize Prevent recent recipient recipients response SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 virus vaccination Vaccine Vaccines variant Viral particles Viral variants virus wild-type SARS-CoV-2 [DOI] 10.7150/ijbs.72424 PMC 바로가기 [Article Type] Review
Serological testing for SARS-CoV-2 antibodies in clinical practice: A comparative diagnostic accuracy study임상 실습에서 SARS-CoV-2 항체에 대한 혈청 검사: 비교 진단 정확도 연구Article Published on 2022-07-012022-09-11 Journal: Allergy [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analytical techniques anti-RBD anti-RBD ELISA Anti-S1 antibody chemiluminescence immunoassay CLIA Clinical practice clinical settings conducted coronavirus coronavirus disease COVID-19 COVID-19 diagnostic testing [Supplementary Concept] defined detect determine diagnostic Diagnostic accuracy diagnostic testing domain electrochemiluminescence immunoassay ELISA enzyme enzyme-linked immunosorbent assays epitope Epitopes health-care host immunity identify IgG immunoassay Infection Infections/*epidemiology/transmission*Disease Outbreaks Infectious disease Infectious diseases Inpatient lateral flow immunoassay likelihood live SARS-CoV-2 measure Nasopharyngeal swab neutralization activity neutralization assays Neutralizing antibodies neutralizing antibody nucleocapsid Patient PCR test performed positive powerful tool Protein RBD Re-infection Real-time PCR Receptor-binding domain respiratory S1/S2 S2 domain SARS-CoV-2 SARS-CoV-2 [Supplementary Concept] SARS-CoV-2 antibodies SARS-CoV-2 antibody sensitivity serological serological test Serological testing Serological tests severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 [Supplementary Concept] specificity Spike protein spike protein. subgroup of patient subgroups subtype university [DOI] 10.1111/all.15206 PMC 바로가기 [Article Type] Article
Evaluation of humoral and cellular response to third dose of BNT162b2 mRNA COVID-19 vaccine in patients treated with B-cell depleting therapyB세포 고갈 요법으로 치료받은 환자에서 BNT162b2 mRNA COVID-19 백신 3차 접종에 대한 체액 및 세포 반응 평가Article Published on 2022-07-012022-09-11 Journal: Journal of autoimmunity [Category] MERS, 바이오마커, 유전자 메커니즘, 진단, [키워드] affected anti-CD20 anti-S anti-SARS-CoV-2 antibody Autoimmune disease B-cell BNT162b2 CD-20 CD20 cellular immunity cellular response Cohort COVID-19 COVID-19 vaccination COVID-19 vaccine depleting dose doses drug group healthy control healthy controls humoral humoral and cellular immunity IFN-g IgG IMID Immune-mediated inflammatory disease Immune-mediated inflammatory diseases immunogenic immunogenicity Immunosuppressed immunosuppressed patient immunosuppressed patients Inflammatory diseases interferon mRNA mRNA COVID-19 vaccine mRNA COVID-19 vaccines naïve Neutralization assay neutralization assays neutralization titer neutralization titers Neutralizing antibodies neutralizing antibody no significant difference of BNT162b2 Patient patients treated Quantitative reduced response seroconverted significant difference significantly spike subject therapy These data treated vaccination vaccination. [DOI] 10.1016/j.jaut.2022.102848 PMC 바로가기 [Article Type] Article
Augmented neutralization of SARS-CoV-2 Omicron variant by boost vaccination and monoclonal antibodies추가 백신 접종 및 단일 클론 항체에 의한 SARS-CoV-2 Omicron 변이체의 증강 중화Article Published on 2022-06-012022-09-11 Journal: European Journal of Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody Antibody binding appearance approved binding BNT162b2 boost boost immunization candidate caused clinically coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Delta delta variant determine dominant Effective vaccines Efficacy Evidence flow cytometry immunization increase MONITOR monoclonal antibodies monoclonal antibody neutralization Neutralization assay neutralization assays neutralize neutralized Neutralizing neutralizing antibody omicron Omicron variant Omicron variants parental pathogenicity Protective pseudotyped SARS-CoV-2 recognize respiratory SARS-CoV-2 SARS-CoV-2 variants serum antibodies serum antibody serum titer serum titers severe acute respiratory syndrome Coronavirus Support therapeutic therapeutic antibodies titers Transmissibility vaccination vaccination. Vaccine variant variants virus variant virus variants Wuhan strain [DOI] 10.1002/eji.202249841 PMC 바로가기 [Article Type] Article
Structures of Omicron spike complexes and implications for neutralizing antibody developmentOmicron 스파이크 복합체의 구조 및 중화 항체 개발에 대한 의미Article Published on 2022-05-032022-09-11 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 antibodies antibody Antibody binding Antibody structure binding biochemical complexes country CP: Immunology CP: Microbiology cryo Cryo-electron microscopy cryo-EM cryo-EM structures Delta dominant drugs electron microscopy Evidence explain Fab immune immune evasion immunology implication information interactions lead Microbiology Mutation mutations neutralization Neutralization antibody neutralization assays neutralizing antibody omicron provide required responsible SARS-CoV-2 spike spike mutation spike mutations Spike. Structure structures the SARS-CoV-2 therapeutic therapeutic antibodies Vaccine variant wild-type [DOI] 10.1016/j.celrep.2022.110770 PMC 바로가기 [Article Type] Article